Article

Novel Strategy against AML by Rescuing Loss of Phase Separation of Pathogenic NPM1c

2025-04-13

Abstract excerpt

<h4>SUMMARY</h4> Nucleophosmin (NPM1) is a nucleolar protein that participates in many biological processes through phase separation. In acute myeloid leukemia (AML), nearly one-third of cases harbor NPM1c mutations. Previous studies mainly focused on the contribution of the additional NES in NPM1c mislocalization and AML development; however, the mechanisms underlying the relationship between aberrant localizat...

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Literature Corpus work: 8cd61d7d-d204-54dc-95a3-9f35ed32ffe1
DOI: 10.1101/2025.04.08.646961

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