Article

PU.1 Shapes Host Epigenetic Responses to Mycobacterium tuberculosis and Represents a Target for Host Directed Therapy

2025-09-12

Abstract excerpt

Mycobacterium tuberculosis ( Mtb ) infection induces widespread epigenetic changes in monocytes and macrophages. To characterize the critical factor responsible for Mtb -induced epigenetic responses, we performed an integrative analyses of chromatin modification (H3K27ac), transcription factor binding, and gene expression in human monocytes and macrophages. Our data identified PU.1 (SPI1) as a key transcriptiona...

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Literature Corpus work: 8cd5c96e-b006-5db5-bfa1-587fe669e8de
DOI: 10.1101/2025.09.09.675072

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