Article

A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective

2023-02-10

Abstract excerpt

<h4>ABSTRACT</h4> Despite mediating several essential processes in the brain, including during development, cyclin-dependent kinase-like 5 (CDKL5) remains a poorly characterized human protein kinase. Accordingly, its substrates, functions, and regulatory mechanisms have not been fully described. We realized that availability of a potent and selective small molecule probe targeting CDKL5 could enable illumination...

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Literature Corpus work: 1c5aca24-3ebe-58a3-b2ed-bda9a4975e9c
DOI: 10.1101/2023.02.09.527935

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