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Selective CDK9 Inhibition by Natural Compound Toyocamycin in Cancer Cells

8 Jul 2022

Abstract excerpt

Aberrant transcription in cancer cells involves the silencing of tumor suppressor genes (TSGs) and activation of oncogenes. Transcriptomic changes are associated with epigenomic alterations such as DNA-hypermethylation, histone deacetylation, and chromatin condensation in promoter regions of silenced TSGs. To discover novel drugs that trigger TSG reactivation in cancer cells, we used a GFP-reporter system whose...

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PMID: 35884401
DOI: 10.3390/cancers14143340

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