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Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

18 Dec 2024

Abstract excerpt

Lithocholic acid (LCA) is accumulated in mammals during calorie restriction and it can activate AMP-activated protein kinase (AMPK) to slow down ageing1. However, the molecular details of how LCA activates AMPK and induces these biological effects are unclear. Here we show that LCA enhances the activity of sirtuins to deacetylate and subsequently inhibit vacuolar H+-ATPase (v-ATPase), which leads to AMPK...

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PMID: 39695235
DOI: 10.1038/s41586-024-08348-2

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