Article

SLP-76/LAT AND-gated CAR-T cells mediate highly specific and durable antitumor activity in pancreatic ductal adenocarcinoma with reduced gastric toxicity

2026-03-23

Abstract excerpt

<title>Abstract</title> <p>Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive human malignancies, characterized by a five-year survival rate of approximately 13 percent and limited therapeutic efficacy. Although Claudin18.2 (CLDN18.2)-directed chimeric antigen receptor (CAR) T cells have demonstrated promising antitumor activity, physiological CLDN18.2 expression in normal gast...

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Literature Corpus work: 27c3fcc7-16a3-5026-bb69-95ddcc9a993b
DOI: 10.21203/rs.3.rs-9121312/v1

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