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A new <i>in vitro</i> checkerboard-parasite reduction ratio interaction assay for early de-risk of clinical development of antimalarial combinations

2022-04-21

Abstract excerpt

The development and spread of drug resistant phenotypes substantially threaten malaria control efforts. Combination therapies have the potential to minimize the risk of resistance development but require intensive preclinical studies to determine optimal combination and dosing regimens. To support the selection of new combinations, we developed a novel in vitro-in silico combination approach to help identify the...

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Literature Corpus work
10e8cd84-e2fe-5032-a937-e2a3c562b826
DOI
10.1101/2022.04.19.488858
Open publication

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