Article

Assessment of the CTCF Binding Sites and Repeat-Positions Upstream the Human <i>H19</i> Gene

2018-01-19

Abstract excerpt

The human H19 and IGF2 genes share an Imprinting Control Region (ICR) that regulates gene expression in a parent-of-origin dependent manner. Understanding of the ICR sequence organization is critical to accurate localization of disease-associated abnormalities including Beckwith-Wiedemann and Silver-Russell syndromes. Previous studies established that the ICR of the H19 - IGF2 imprinted domain included several...

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Literature Corpus work: 8cb908cf-010c-5575-be14-b119169933a0
DOI: 10.1101/250407

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