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Dysregulated <i>H19</i> / <i>Igf2</i> expression disrupts cardiac-placental axis during development of Silver Russell Syndrome-like mouse models

2022-03-28

Abstract excerpt

Dysregulation of the imprinted H19/IGF2 locus can lead to Silver-Russell Syndrome (SRS) in humans. However, the mechanism of how abnormal H19/IGF2 expression contributes to various SRS phenotypes remains unclear, largely due to incomplete understanding of the developmental functions of these two genes. We previously generated a mouse model with humanized H19/IGF2 ICR ( hIC1 ) on the paternal allele that exhibi...

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Literature Corpus work
ae455c28-8968-5281-bfce-a040adf367bd
DOI
10.1101/2022.03.28.486058
Open publication

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Dysregulated <i>H19</i> / <i>Igf2</i> expression disrupts cardiac-placental axis during development of Silver Russell Syndrome-like mouse modelsDOI 10.1101/2022.03.28.486058
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