Article

Identification of the sequences responsible for maternal <i>H19</i> -ICR hypermethylation with Beckwith-Wiedemann syndrome-like overgrowth in mice

2024-07-10

Abstract excerpt

Beckwith-Wiedemann syndrome (BWS) is caused by a gain of methylation (GOM) at the imprinting control region within the Igf2-H19 domain on the maternal allele ( H19 -ICR GOM). Mutations in the binding sites of several transcription factors are involved in H19 -ICR GOM and BWS. However, the responsible sequence(s) for H19 -ICR GOM with BWS-like overgrowth has not been identified in mice. Here, we report that a m...

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Literature Corpus work: da3743a1-66da-505a-bc50-3fda9fdd1054
DOI: 10.1101/2024.07.07.602442

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