Article
Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study.
PLoS genetics - 1 Oct 2017
Davis James P, Huyghe Jeroen R, Locke Adam E, Jackson Anne U, Sim Xueling, Stringham Heather M, Teslovich Tanya M, Welch Ryan P, Fuchsberger Christian, Narisu Narisu, Chines Peter S, Kangas Antti J, Soininen Pasi, Ala-Korpela Mika, Kuusisto Johanna, Collins Francis S, Laakso Markku, Boehnke Michael, Mohlke Karen L
Abstract excerpt
Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based association tests between 15.1M variants from genome-wide and exome array and imputed genotypes and 72 lipid and lipoprotein traits in 8,372 Finns. After accounting for 885 variants at 157...
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