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An atlas of bacterial serine-threonine kinases reveals functional diversity and key distinctions from eukaryotic kinases

6 May 2025

Abstract excerpt

Bacterial serine-threonine kinases (STKs) regulate diverse cellular processes associated with cell growth, virulence, and pathogenicity and are evolutionarily related to the druggable eukaryotic STKs. A deeper understanding of how bacterial STKs differ from their eukaryotic counterparts and how they have evolved to regulate diverse bacterial signaling functions is crucial for advancing the discovery and...

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PMID: 40327749
DOI: 10.1126/scisignal.adt8686

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