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Relaxation of cardiac pericytes by GLP-1 activating K <sub>ATP</sub> channels mediates remote ischaemic preconditioning cardioprotection

2025-06-30

Abstract excerpt

Failure to reperfuse the coronary microvasculature (“no-reflow”) affects up to 50% of patients after unblocking a coronary artery that caused ischaemia and acute myocardial infarction. No-reflow is associated with reduced left ventricular ejection fraction, increased infarct size and death. We have established that no-reflow results from cardiac pericytes constricting coronary capillaries, and that pharmacological...

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Identifiers and source

Literature Corpus work
7e232efc-4d68-5383-a285-f2b7df4bb47a
DOI
10.1101/2025.06.26.661857
Open publication

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Relaxation of cardiac pericytes by GLP-1 activating K <sub>ATP</sub> channels mediates remote ischaemic preconditioning cardioprotectionDOI 10.1101/2025.06.26.661857
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