Article
Endothelial C-Type Natriuretic Peptide Acts on Pericytes to Regulate Microcirculatory Flow and Blood Pressure.
Circulation - 31 Jul 2018
Špiranec Katarina, Chen Wen, Werner Franziska, Nikolaev Viacheslav O, Naruke Takashi, Koch Franziska, Werner Andrea, Eder-Negrin Petra, Diéguez-Hurtado Rodrigo, Adams Ralf H, Baba Hideo A, Schmidt Hannes, Schuh Kai, Skryabin Boris V, Movahedi Kiavash, Schweda Frank, Kuhn Michaela
Abstract excerpt
BACKGROUND: Peripheral vascular resistance has a major impact on arterial blood pressure levels. Endothelial C-type natriuretic peptide (CNP) participates in the local regulation of vascular tone, but the target cells remain controversial. The cGMP-producing guanylyl cyclase-B (GC-B) receptor for CNP is expressed in vascular smooth muscle cells (SMCs). However, whereas endothelial cell-specific CNP knockout mice...
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