Article

PVT1/miR-148a-3p/MKL1 axis regulates brain damage in children with congenital heart disease

2025-08-27

Abstract excerpt

<title>Abstract</title> <p><bold>Objectives:</bold> To analyze the role of lncRNA PVT1 in cerebral ischemia-reperfusion (I/R) injury induced by deep hypothermia low flow (DHLF). <bold>Methods and results: </bold>PVT1 expression was significantly downregulated in DHLF mouse brain tissue, preoperative and postoperative blood samples from children undergoing DHLF extracorporeal circulation, and hOGD-treated cells. I...

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Literature Corpus work: 9b65e2b9-e651-59b0-9e94-eaf17fbd8840
DOI: 10.21203/rs.3.rs-7166990/v1

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