Article

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine-resistance in breast cancer

2018-08-03

Abstract excerpt

Tumor hypoxia is associated with poor patient outcomes in estrogen receptor-α (ERα) positive breast cancer. Hypoxia is known to affect tumor growth by reprogramming metabolism and regulating amino acid (AA) uptake. Here we show that the glutamine transporter, SNAT2, is the AA transporter most frequently induced by hypoxia in breast cancer and it is regulated by HIF1α both in-vitro and in-vivo in xenografts. SNAT...

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Literature Corpus work: 71877abd-0049-5cf3-9aa6-79b5d8dd7d36
DOI: 10.1101/384628

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