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Article

NDRG2 ablation reprograms metastatic cancer cells towards glutamine dependence via the induction of ASCT2

1 Jan 2020

Abstract excerpt

Background: Metastasis is the most common cause of lethal outcome in various types of cancers. Although the cell proliferation related metabolism rewiring has been well characterized, less is known about the association of metabolic changes with tumor metastasis. Herein, we demonstrate that metastatic tumor obtained a mesenchymal phenotype, which is obtained by the loss of tumor suppressor NDRG2 triggered...

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PMID: 33162818
DOI: 10.7150/ijbs.48066

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