Article

Identification of New Drugs to Counteract Anti-Spike IgG-Induced Hyperinflammation in Severe COVID-19

2023-01-20

Abstract excerpt

Previously, we and others have shown that SARS-CoV-2 spike-specific IgG antibodies play a major role in disease severity in COVID-19 by triggering macrophage hyperactivation, disrupting endothelial barrier integrity, and inducing thrombus formation. This hyperinflammation is dependent on high levels of anti-spike IgG with aberrant Fc tail glycosylation, leading to Fcγ receptor hyperactivation. For development of i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 979567ae-03fc-5c1a-9836-2fe182d7b356
DOI: 10.2139/ssrn.4327343

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of New Drugs to Counteract Anti-Spike IgG-Induced Hyperinflammation in Severe COVID-19DOI 10.2139/ssrn.4327343Read

Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19Semantic proximity Read

Neutralizing anti-spike monoclonal antibodies for COVID-19 in vulnerable populations: lessons learned and future directions.Semantic proximity Read

Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesisSemantic proximity Read

Complement Inhibition and COVID-19: The Story so FarSemantic proximity Read

SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet pro-coagulant activitySemantic proximity Read

SARS-CoV-2 spike protein activates NOX2-p66SHC axis via inhibiting SLAMF8 to promote thrombogenesisSemantic proximity Read

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κBSemantic proximity Read

Machine Learning Identifies Ponatinib as a Potent Inhibitor of SARS-CoV2-induced Cytokine StormSemantic proximity Read

SARS-CoV-2-Triggered Mast Cell Rapid Degranulation Induces Alveolar Epithelial Inflammation and Lung InjurySemantic proximity Read

Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition moleculesSemantic proximity Read

A novel antibody against the furin cleavage site of SARS-CoV-2 spike protein: Effects on proteolytic cleavage and ACE2 binding.Semantic proximity Read

A zebrafish model of COVID-19-associated cytokine storm syndrome reveals differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concernSemantic proximity Read