Article

Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19

2022-12-21

Abstract excerpt

<h4>Summary</h4> Previously, we and others have shown that SARS-CoV-2 spike-specific IgG antibodies play a major role in disease severity in COVID-19 by triggering macrophage hyperactivation, disrupting endothelial barrier integrity, and inducing thrombus formation. This hyper-inflammation is dependent on high levels of anti-spike IgG with aberrant Fc tail glycosylation, leading to Fcγ receptor hyper-activation....

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Literature Corpus work: cd2afaaa-99f2-5d90-b790-f6bd8f6bae8f
DOI: 10.1101/2022.12.20.521247

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