Back to search

Article

Sex-specific developmental phenotypes and their response to neonatal <i>Dyrk1a</i> reduction in the Ts65Dn Down syndrome mouse model

2026-07-17

Abstract excerpt

<h4>ABSTRACT</h4> Children with Down syndrome (DS) experience delays in cognitive, physical, and motor development. Overexpression of Dual-specificity tyrosine phosphorylation-regulated kinase-1A ( DYRK1A ), a gene on human chromosome 21 (Hsa21) and triplicated in individuals with Trisomy 21, contributes to neurodevelopmental delays associated with DS, and is a candidate for therapies to improve neurodevelopmen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
53de2a6e-2e16-5a12-bc21-bde98e987fad
DOI
10.64898/2026.07.15.738703
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Sex-specific developmental phenotypes and their response to neonatal <i>Dyrk1a</i> reduction in the Ts65Dn Down syndrome mouse modelDOI 10.64898/2026.07.15.738703
Sex specific emergence of trisomic <i>Dyrk1a</i> -related skeletal phenotypes in the development of a Down syndrome mouse modelSemantic proximity
Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse modelSemantic proximity
Sexually dimorphic DYRK1A overexpression on postnatal day 15 in the Ts65Dn mouse model of Down syndrome: Effects of pharmacological targeting on behavioral phenotypes.Semantic proximity
LONG-TERM NEURODEVELOPMENTAL AND COGNITIVE OUTCOMES FOLLOWING PRENATAL INHIBITION OF DYRK1A BY LEUCETTINE L41 IN MOUSE MODELS OF DOWN SYNDROMESemantic proximity
Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes.Semantic proximity
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndromeSemantic proximity
The impact of <i>Mmu</i> 17 non- <i>Hsa</i> 21 orthologous genes in the Ts65Dn mouse model of Down syndrome: the “gold standard” revisitedSemantic proximity
Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome.Semantic proximity
Sex-specific trisomic Dyrk1a-related skeletal phenotypes during development in a Down syndrome model.Semantic proximity
Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down SyndromeSemantic proximity
Dyrk1a from Gene Function in Development and Physiology to Dosage Correction across Life Span in Down SyndromeSemantic proximity
DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down SyndromeSemantic proximity
Select a neighboring publication to make it the new centre.