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Article

Mouse Models for Down Syndrome-Associated Developmental Cognitive Disabilities

1 Jan 2011

Abstract excerpt

Down syndrome (DS) is mainly caused by the presence of an extra copy of human chromosome 21 (Hsa21) and is a leading genetic cause for developmental cognitive disabilities in humans. The mouse is a premier model organism for DS because the regions on Hsa21 are syntenically conserved with three regions in the mouse genome, which are located on mouse chromosome 10 (Mmu10), Mmu16 and Mmu17. With the advance of...

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PMID: 21865664
DOI: 10.1159/000329422

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