Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IDO1 inhibitor enhances the effectiveness of PD-1 blockade in microsatellite stable colorectal cancer by promoting macrophage pro-inflammatory phenotype polarization.

Cancer immunology, immunotherapy : CII - 3 Jan 2025

Guangzhao Lv, Xin Wang, Miaoqing Wu, Wenjuan Ma, Ranyi Liu, Zhizhong Pan, Rongxin Zhang, Gong Chen

Abstract excerpt

Microsatellite stable (MSS) colorectal cancer (CRC) is a subtype of CRC that generally exhibits resistance to immunotherapy, particularly immune checkpoint inhibitors such as PD-1 blockade. This study investigates the effects and underlying mechanisms of combining PD-1 blockade with IDO1 inhibition in MSS CRC. Bioinformatics analyses of TCGA-COAD and TCGA-READ cohorts revealed significantly elevated IDO1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to Immune Checkpoint Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Indoleamine-Pyrrole 2,3,-Dioxygenase

Share to Macrophages

Share to Microsatellite Instability

Share to Programmed Cell Death 1 Receptor

Share to Tumor Microenvironment

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 39751692
DOI: 10.1007/s00262-024-03925-w
PMCID: PMC11699167

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IDO1 inhibitor enhances the effectiveness of PD-1 blockade in microsatellite stable colorectal cancer by promoting macrophage pro-inflammatory phenotype polarization.PMID 39751692Read ↗

Evaluating the role of IDO1 macrophages in immunotherapy using scRNA-seq and bulk-seq in colorectal cancerSemantic proximity Read ↗

Molecular characteristics of microsatellite stable early-onset colorectal cancer as predictors of prognosis and immunotherapeutic responseSemantic proximity Read ↗

The next bastion to be conquered in immunotherapy: microsatellite stable colorectal cancerSemantic proximity Read ↗

A subset of patients with MSS/MSI‑low‑colorectal cancer showed increased CD8(+) TILs together with up‑regulated IFN‑γSemantic proximity Read ↗

Single-cell sequencing reveals the immune microenvironment landscape related to anti-PD-1 resistance in metastatic colorectal cancer with high microsatellite instabilitySemantic proximity Read ↗

PLXDC1 serves as a potential prognostic marker and involves in malignant progression and macrophage polarization in colon cancerSemantic proximity Read ↗

miR-448 targets IDO1 and regulates CD8+ T cell response in human colon cancerSemantic proximity Read ↗

The Mechanisms Leading to Distinct Responses to PD-1/PD-L1 Blockades in Colorectal Cancers With Different MSI StatusesSemantic proximity Read ↗

Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside.Semantic proximity Read ↗

Coordinated macrophage and T cell interactions mediate response to checkpoint blockade in colorectal cancerSemantic proximity Read ↗

Immune overdrive signature in colorectal tumor subset predicts poor clinical outcomeSemantic proximity Read ↗

ACB1801 enhances tumor immunogenicity by targeting glycolysis/ferroptosis vulnerability and activating STAT1-signaling to overcome anti-PD-1 resistance in MSS colorectal cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.