Article
Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2018
Garsed Dale W, Alsop Kathryn, Fereday Sian, Emmanuel Catherine, Kennedy Catherine J, Etemadmoghadam Dariush, Gao Bo, Gebski Val, Garès Valérie, Christie Elizabeth L, Wouters Maartje C A, Milne Katy, George Joshy, Patch Ann-Marie, Li Jason, Arnau Gisela Mir, Semple Timothy, Gadipally Sreeja R, Chiew Yoke-Eng, Hendley Joy, Mikeska Thomas, Zapparoli Giada V, Amarasinghe Kaushalya, Grimmond Sean M, Pearson John V, Waddell Nicola, Hung Jillian, Stewart Colin J R, Sharma Raghwa, Allan Prue E, Rambau Peter F, McNally Orla, Mileshkin Linda, Hamilton Anne, Ananda Sumitra, Grossi Marisa, Cohen Paul A, Leung Yee C, Rome Robert M, Beale Philip, Blomfield Penny, Friedlander Michael, Brand Alison, Dobrovic Alexander, Köbel Martin, Harnett Paul, Nelson Brad H, Bowtell David D L, deFazio Anna
Abstract excerpt
Purpose: Women with epithelial ovarian cancer generally have a poor prognosis; however, a subset of patients has an unexpected dramatic and durable response to treatment. We sought to identify clinical, pathological, and molecular determinants of exceptional survival in women with high-grade serous cancer (HGSC), a disease associated with the majority of ovarian cancer deaths.Experimental Design: We evaluated the...
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