Article

Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA

2021-02-23

Abstract excerpt

Maternal loss of imprinting (LOI) at the H19/IGF2 locus results in biallelic IGF2 and reduced H19 expression and is associated with Beckwith Wiedemann syndrome (BWS). We use mouse models for LOI to understand the relative importance of Igf2 and H19 mis-expression in BWS phenotypes. Here we focus on cardiovascular phenotypes and show that neonatal cardiomegaly is exclusively dependent on increased Igf2 . Circ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8bb06770-e5a5-53ef-b57d-6b82ff51cc87
DOI: 10.1101/2021.02.23.432554

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNADOI 10.1101/2021.02.23.432554Read

Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA.Semantic proximity Read

Dysregulated <i>H19</i> / <i>Igf2</i> expression disrupts cardiac-placental axis during development of Silver Russell Syndrome-like mouse modelsSemantic proximity Read

Loss of imprinting mutations define both distinct and overlapping roles for misexpression of IGF2 and of H19 lncRNA.Semantic proximity Read

Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes.Semantic proximity Read

Balancing LncRNA H19 and miR‐675 Bioconversion as a Key Regulator of Embryonic Myogenesis Under Maternal ObesitySemantic proximity Read

Perinatal lethality in H19 enhancers-Igf2 transgenic mice.Semantic proximity Read

Loss of imprinting of the Igf2-H19 ICR1 enhances placental endocrine capacity via sex-specific alterations in signalling pathways in the mouseSemantic proximity Read

H19 acts as a trans regulator of the imprinted gene network controlling growth in mice.Semantic proximity Read

Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesisSemantic proximity Read

Humanized H19/Igf2 locus reveals diverged imprinting mechanism between mouse and human and reflects Silver-Russell syndrome phenotypes.Semantic proximity Read

Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophySemantic proximity Read

A dataset of adult heart and liver mass after placental <i>Insulin-like growth factor 1</i> overexpression and insufficiency in miceSemantic proximity Read