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Article

Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA.

eLife - 17 Aug 2021

Park Ki-Sun, Rahat Beenish, Lee Hyung Chul, Yu Zu-Xi, Noeker Jacob, Mitra Apratim, Kean Connor M, Knutsen Russell H, Springer Danielle, Gebert Claudia M, Kozel Beth A, Pfeifer Karl

Abstract excerpt

Maternal loss of imprinting (LOI) at the H19/IGF2 locus results in biallelic IGF2 and reduced H19 expression and is associated with Beckwith--Wiedemann syndrome (BWS). We use mouse models for LOI to understand the relative importance of Igf2 and H19 mis-expression in BWS phenotypes. Here we focus on cardiovascular phenotypes and show that neonatal cardiomegaly is exclusively dependent on increased Igf2....

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Identifiers

PMID: 34402430
DOI: 10.7554/eLife.67250
PMCID: PMC8425947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA.PMID 34402430Read ↗

Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNASemantic proximity Read ↗

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