Perinatal lethality in H19 enhancers-Igf2 transgenic mice.

doi:10.1002/(SICI)1098-2795(199710)48:2<194::AID-MRD7>3.0.CO;2-N

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Article

Perinatal lethality in H19 enhancers-Igf2 transgenic mice.

Molecular reproduction and development - 1 Oct 1997

Wise T L, Pravatcheva D D

Abstract excerpt

The insulin-like growth factor II (IGFII) is a mitogen for a number of cell types in vitro and is required for normal embryonic growth. It has been hypothesized that overexpression of IGF2 is responsible for the increased growth and tumor predisposition in patients with Beckwith-Wiedemann syndrom...

Topics

Animals
DNA
DNA Methylation
Enhancer Elements, Genetic
Fetal Death
Genes, Tumor Suppressor
Heterozygote
Homozygote
Insulin-Like Growth Factor II
Mice
Mice, Transgenic
Microinjections
Muscle Proteins
Phenotype
Promoter Regions, Genetic
RNA, Long Noncoding
RNA, Untranslated

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