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Article

Humanized H19/Igf2 locus reveals diverged imprinting mechanism between mouse and human and reflects Silver-Russell syndrome phenotypes.

Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 2016

Hur Stella K, Freschi Andrea, Ideraabdullah Folami, Thorvaldsen Joanne L, Luense Lacey J, Weller Angela H, Berger Shelley L, Cerrato Flavia, Riccio Andrea, Bartolomei Marisa S

Abstract excerpt

Genomic imprinting affects a subset of genes in mammals, such that they are expressed in a monoallelic, parent-of-origin-specific manner. These genes are regulated by imprinting control regions (ICRs), cis-regulatory elements that exhibit allele-specific differential DNA methylation. Although genomic imprinting is conserved in mammals, ICRs are genetically divergent across species. This raises the fundamental...

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Identifiers

PMID: 27621468
DOI: 10.1073/pnas.1603066113
PMCID: PMC5047210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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