Article
Humanized H19/Igf2 locus reveals diverged imprinting mechanism between mouse and human and reflects Silver-Russell syndrome phenotypes.
Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 2016
Hur Stella K, Freschi Andrea, Ideraabdullah Folami, Thorvaldsen Joanne L, Luense Lacey J, Weller Angela H, Berger Shelley L, Cerrato Flavia, Riccio Andrea, Bartolomei Marisa S
Abstract excerpt
Genomic imprinting affects a subset of genes in mammals, such that they are expressed in a monoallelic, parent-of-origin-specific manner. These genes are regulated by imprinting control regions (ICRs), cis-regulatory elements that exhibit allele-specific differential DNA methylation. Although genomic imprinting is conserved in mammals, ICRs are genetically divergent across species. This raises the fundamental...
Topics
- Alleles
- Animals
- DNA Methylation
- Embryo, Mammalian
- Female
- Gene Targeting
- Genetic Loci
- Genomic Imprinting
- Histones
- Humans
- Insulin-Like Growth Factor II
- Lysine
- Male