Article
Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes.
Genes & development - 1 Dec 1997
Eggenschwiler J, Ludwig T, Fisher P, Leighton P A, Tilghman S M, Efstratiadis A
Abstract excerpt
In mice, the imprinted Igf2 gene (expressed from the paternal allele), which encodes a growth-promoting factor (IGF-II), is linked closely to the reciprocally imprinted H19 locus on chromosome 7. Also imprinted (expressed from the maternal allele) is the Igf2r gene on chromsome 17 encoding the ty...
Topics
- Abnormalities, Multiple
- Adrenal Cortex
- Animals
- Beckwith-Wiedemann Syndrome
- Bone and Bones
- Cleft Palate
- Crosses, Genetic
- Cyclin-Dependent Kinase Inhibitor p57
- Disease Models, Animal
- Eye Abnormalities
- Female
- Fetal Death
- Fetus
- Gene Expression Regulation, Developmental