Article
H19 acts as a trans regulator of the imprinted gene network controlling growth in mice.
Development (Cambridge, England) - 1 Oct 2009
Gabory Anne, Ripoche Marie-Anne, Le Digarcher Anne, Watrin Françoise, Ziyyat Ahmed, Forné Thierry, Jammes Hélène, Ainscough Justin F X, Surani M Azim, Journot Laurent, Dandolo Luisa
Abstract excerpt
The imprinted H19 gene produces a non-coding RNA of unknown function. Mice lacking H19 show an overgrowth phenotype, due to a cis effect of the H19 locus on the adjacent Igf2 gene. To explore the function of the RNA itself, we produced transgenic mice overexpressing H19. We observed postnatal growth reduction in two independent transgenic lines and detected a decrease of Igf2 expression in embryos. An extensive...
Topics
- Animals
- Female
- Gene Expression Regulation, Developmental
- Gene Regulatory Networks
- Insulin-Like Growth Factor II
- Male
- Mice
- Mice, Transgenic
- Phenotype
- RNA, Long Noncoding
- RNA, Untranslated
- Regulatory Sequences, Nucleic Acid