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<i> Prpf8 <sup>N1531S</sup> </i> homozygous mutant mouse embryos have multiple defects in cardiac development and show aberrant splicing of the cardiac transcription factor <i>Tead1</i>

2026-04-21

Abstract excerpt

Mutations in the spliceosomal gene PRPF8 are associated with a range of human diseases. Studies in mouse and zebrafish suggest that Prpf8 also has a developmental function. Here, using a Prpf8 mutant mouse line isolated from a chemical induced mutagenesis screen, we uncover a previously unrecognised and essential role for Prpf8 in heart development, consistent with the embryonic lethality observed in Prpf8 N...

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Literature Corpus work
8ba89276-5e6f-599b-836a-ff61f75c9102
DOI
10.64898/2026.04.17.719138
Open publication

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<i> Prpf8 <sup>N1531S</sup> </i> homozygous mutant mouse embryos have multiple defects in cardiac development and show aberrant splicing of the cardiac transcription factor <i>Tead1</i>DOI 10.64898/2026.04.17.719138
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