Article
TEAD1 trapping by the Q353R-Lamin A/C causes dilated cardiomyopathy.
Science advances - 14 Apr 2023
Yamada Shintaro, Ko Toshiyuki, Ito Masamichi, Sassa Tatsuro, Nomura Seitaro, Okuma Hiromichi, Sato Mayuko, Imasaki Tsuyoshi, Kikkawa Satoshi, Zhang Bo, Yamada Takanobu, Seki Yuka, Fujita Kanna, Katoh Manami, Kubota Masayuki, Hatsuse Satoshi, Katagiri Mikako, Hayashi Hiromu, Hamano Momoko, Takeda Norifumi, Morita Hiroyuki, Takada Shuji, Toyoda Masashi, Uchiyama Masanobu, Ikeuchi Masashi, Toyooka Kiminori, Umezawa Akihiro, Yamanishi Yoshihiro, Nitta Ryo, Aburatani Hiroyuki, Komuro Issei
Abstract excerpt
Mutations in the LMNA gene encoding Lamin A and C (Lamin A/C), major components of the nuclear lamina, cause laminopathies including dilated cardiomyopathy (DCM), but the underlying molecular mechanisms have not been fully elucidated. Here, by leveraging single-cell RNA sequencing (RNA-seq), assay for transposase-accessible chromatin using sequencing (ATAC-seq), protein array, and electron microscopy analysis, we...
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