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Article

Alternative Splicing Regulator RBM20 and Cardiomyopathy

28 Nov 2018

Abstract excerpt

RBM20 is a vertebrate-specific RNA-binding protein with two zinc finger (ZnF) domains, one RNA-recognition motif (RRM)-type RNA-binding domain and an arginine/serine (RS)-rich region. RBM20 has initially been identified as one of dilated cardiomyopathy (DCM)-linked genes. RBM20 is a regulator of heart-specific alternative splicing and Rbm20ΔRRM mice lacking the RRM domain are defective in the splicing regulation....

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PMID: 30547036
DOI: 10.3389/fmolb.2018.00105

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