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Article

Tropomyosin 1: Multiple roles in the developing heart and in the formation of congenital heart defects.

Journal of molecular and cellular cardiology - 1 May 2017

England Jennifer, Granados-Riveron Javier, Polo-Parada Luis, Kuriakose Diji, Moore Christopher, Brook J David, Rutland Catrin S, Setchfield Kerry, Gell Christopher, Ghosh Tushar K, Bu'Lock Frances, Thornborough Christopher, Ehler Elisabeth, Loughna Siobhan

Abstract excerpt

Tropomyosin 1 (TPM1) is an essential sarcomeric component, stabilising the thin filament and facilitating actin's interaction with myosin. A number of sarcomeric proteins, such as alpha myosin heavy chain, play crucial roles in cardiac development. Mutations in these genes have been linked to congenital heart defects (CHDs), occurring in approximately 1 in 145 live births. To date, TPM1 has not been associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28359939
DOI: 10.1016/j.yjmcc.2017.03.006
PMCID: PMC5441184

Genes

TPM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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