Article

Noncoding elements within <i>MYCN</i> mRNA are autonomous drivers of oncogenesis in neuroblastoma

2025-01-14

Abstract excerpt

Neuroblastoma (NB) is a highly metastatic pediatric cancer arising from the neural crest lineage. Genetic amplification of the MYCN proto-oncogene is a defining feature of NB, present in about 20% of all cases. The let-7 tumor suppressor microRNA targets the 3’ UTR of MYCN mRNA. We previously demonstrated that the 3’ UTR of MYCN mRNA acquires the ability to sequester let-7 in MYCN -amplified ( MA ) disease,...

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Literature Corpus work: 8ba4725e-f04c-53ca-9bbb-2918a9d877de
DOI: 10.1101/2025.01.10.632492

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