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Article

MYCN regulates oncogenic MicroRNAs in neuroblastoma

17 Oct 2007

Abstract excerpt

MYCN amplification is a common feature of aggressive tumour biology in neuroblastoma. The MYCN transcription factor has been demonstrated to induce or repress expression of numerous genes. MicroRNAs (miRNA) are a recently discovered class of short RNAs that repress translation and promote mRNA degradation by sequence-specific interaction with mRNA. Here, we sought to analyse the role of MYCN in regulation of...

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PMID: 17943719
DOI: 10.1002/ijc.23153

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