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Inhibition of OCT4 Binding at the <i>MYCN</i> Locus Induces Neuroblastoma Cell Death Accompanied by Downregulation of Transcripts with High-Open Reading Frame Dominance

2023-06-10

Abstract excerpt

Amplification of MYCN is observed in high-risk neuroblastomas (NBs) and is associated with a poor prognosis. MYCN expression is directly regulated by multiple transcription factors, including OCT4, MYCN, CTCF, and p53 in NB. Our previous study showed that inhibition of p53 binding at the MYCN locus induces NB cell death. However, it remains unclear whether other transcription factors contribute to NB cell survi...

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Literature Corpus work
ded53e1c-8e55-5ea6-be86-5773485a9e80
DOI
10.1101/2023.06.08.544289
Open publication

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Inhibition of OCT4 Binding at the <i>MYCN</i> Locus Induces Neuroblastoma Cell Death Accompanied by Downregulation of Transcripts with High-Open Reading Frame DominanceDOI 10.1101/2023.06.08.544289
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