Functional interplay between <scp>MYCN</scp>,<scp> NCYM</scp>, and <scp>OCT</scp>4 promotes aggressiveness of human neuroblastomas

Abstract excerpt

Neuroblastoma is a pediatric solid tumor that originates from embryonic neural crest cells. The MYCN gene locus is frequently amplified in unfavorable neuroblastomas, and the gene product promotes the progression of neuroblastomas. However, the molecular mechanisms by which MYCN amplification contributes to stem cell-like states of neuroblastoma remain elusive. In this study, we show that MYCN and its...

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