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Article

N-myc and Noncoding RNAs in Neuroblastoma

31 Aug 2012

Abstract excerpt

Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Amplification and overexpression of the MYCN proto-oncogene occurs in approximately 20% of neuroblastomas and is associated with advanced stage disease, rapid tumor progression, and poor prognosis. MYCN encodes the transcriptional regulator N-myc, which has been shown to both up- and downregulate many target genes involved in cell cycle, DNA...

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PMID: 22936790
DOI: 10.1158/1541-7786.mcr-12-0244

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