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Article

Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma

7 Jun 2011

Abstract excerpt

BACKGROUND: MicroRNAs (miRNAs) regulate expression of many cancer-related genes through posttranscriptional repression of their mRNAs. In this study we investigate the proto-oncogene MYCN as a target for miRNA regulation. METHODS: A luciferase reporter assay was used to investigate software-predicted miRNA target sites in the 3'-untranslated region (3'UTR) of MYCN. The miRNAs were overexpressed in cell lines by...

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Identifiers

PMID: 21654684
DOI: 10.1038/bjc.2011.220

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Related research

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Research trail→

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Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastomaPMID 21654684Read ↗

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MYCN-targeting miRNAs are predominantly downregulated during MYCN-driven neuroblastoma tumor formationSemantic proximity Read ↗

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Network Modeling of microRNA–mRNA Interactions in Neuroblastoma Tumorigenesis Identifies miR-204 as a Direct Inhibitor of MYCNSemantic proximity Read ↗

The MicroRNA Landscape of MYCN-Amplified NeuroblastomaSemantic proximity Read ↗

A Genome-Wide Search for Promoters That Respond to Increased MYCN Reveals Both New Oncogenic and Tumor Suppressor MicroRNAs Associated with Aggressive NeuroblastomaSemantic proximity Read ↗

miRNA Expression Profiling of the Murine TH-MYCN Neuroblastoma Model Reveals Similarities with Human Tumors and Identifies Novel Candidate MiRNAsSemantic proximity Read ↗

microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in NeuroblastomaSemantic proximity Read ↗

MicroRNA Let-7a Down-regulates MYC and Reverts MYC-Induced Growth in Burkitt Lymphoma CellsSemantic proximity Read ↗

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