Article

<i>Trans</i> control of cardiac mRNA translation in a protein length-dependent fashion

2020-06-06

Abstract excerpt

<h4>ABSTRACT</h4> Little is known about the impact of naturally occurring genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate how genetic influences on mRNA translational efficiency are associated with complex disease phenotypes using a panel of rat recombinant inbred lines. We identify a locus for cardiac hypertrophy that is associated with a translatome-wide and...

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Literature Corpus work: 8ba0b23a-5ca0-5044-be6e-c9d0a2c02c74
DOI: 10.1101/2020.06.05.133298

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