Article
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.
Genome biology - 28 Jun 2021
Witte Franziska, Ruiz-Orera Jorge, Mattioli Camilla Ciolli, Blachut Susanne, Adami Eleonora, Schulz Jana Felicitas, Schneider-Lunitz Valentin, Hummel Oliver, Patone Giannino, Mücke Michael Benedikt, Šilhavý Jan, Heinig Matthias, Bottolo Leonardo, Sanchis Daniel, Vingron Martin, Chekulaeva Marina, Pravenec Michal, Hubner Norbert, van Heesch Sebastiaan
Abstract excerpt
BACKGROUND: Little is known about the impact of trans-acting genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate the influence of such distant genetic loci on the efficiency of mRNA translation and define their contribution to the development of complex disease phenotypes within a panel of rat recombinant inbred lines. RESULTS: We identify several tissue-specific...
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