Article
Translational regulation shapes the molecular landscape of complex disease phenotypes.
Nature communications - 26 May 2015
Schafer Sebastian, Adami Eleonora, Heinig Matthias, Rodrigues Katharina E Costa, Kreuchwig Franziska, Silhavy Jan, van Heesch Sebastiaan, Simaite Deimante, Rajewsky Nikolaus, Cuppen Edwin, Pravenec Michal, Vingron Martin, Cook Stuart A, Hubner Norbert
Abstract excerpt
The extent of translational control of gene expression in mammalian tissues remains largely unknown. Here we perform genome-wide RNA sequencing and ribosome profiling in heart and liver tissues to investigate strain-specific translational regulation in the spontaneously hypertensive rat (SHR/Ola). For the most part, transcriptional variation is equally apparent at the translational level and there is limited...
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