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Article

Aerobic exercise partially improves the skeletal muscle phenotype in a model of heart failure with preserved ejection fraction in male mice.

Physiological reports - 1 Jun 2026

Martínez Martínez Cielo, Fragoso Medina Jorge, Bravo Sánchez Estefanía, Nieblas Bianca, Saavedra Molina Alfredo, Cortés Rojo Christian, Manzo Ávalos Salvador, García Noemí, Montoya Pérez Rocío

Abstract excerpt

Heart failure with preserved ejection fraction (HFpEF) is associated with skeletal muscle dysfunction that contributes to exercise intolerance and disease progression. Altered Ca2+ homeostasis and increased oxidative stress have been proposed as mechanisms underlying muscle weakness in HFpEF; however, the effects of aerobic exercise on skeletal muscle physiology in this condition remain unclear. This study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ryanodine Receptor Calcium Release Channel

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Identifiers

PMID: 42244187
DOI: 10.14814/phy2.70962
PMCID: PMC13238686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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