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Article

Heart specific knockout of Ndufs4 ameliorates ischemia reperfusion injury.

Journal of molecular and cellular cardiology - 1 Oct 2018

Zhang Huiliang, Gong Guohua, Wang Pei, Zhang Zhen, Kolwicz Stephen C, Rabinovitch Peter S, Tian Rong, Wang Wang

Abstract excerpt

RATIONALE: Ischemic heart disease (IHD) is a leading cause of mortality. The most effective intervention for IHD is reperfusion, which ironically causes ischemia reperfusion (I/R) injury mainly due to oxidative stress-induced cardiomyocyte death. The exact mechanism and site of reactive oxygen species (ROS) generation during I/R injury remain elusive. OBJECTIVE: We aim to test the hypothesis that Complex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30165037
DOI: 10.1016/j.yjmcc.2018.08.022
PMCID: PMC6192835

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