Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tailoring recombinant protein quality by rational media design

10 Apr 2015

Abstract excerpt

Clinical efficacy and safety of recombinant proteins are closely associated with their structural characteristics. The major quality attributes comprise glycosylation, charge variants (oxidation, deamidation, and C- & N-terminal modifications), aggregates, low-molecular-weight species (LMW), and misincorporation of amino acids in the protein backbone. Cell culture media design has a great potential to modulate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Monoclonal and Polyclonal Antibodies Research
Share to Protein purification and stability
Share to Viral Infectious Diseases and Gene Expression in Insects

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25864704
DOI: 10.1002/btpr.2089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tailoring recombinant protein quality by rational media designPMID 25864704Read ↗

Impact of cell culture on recombinant monoclonal antibody product heterogeneitySemantic proximity Read ↗

Effect of different cell culture media on the production and glycosylation of a monoclonal antibody from a CHO cell lineSemantic proximity Read ↗

Impact of cell culture media additives on IgG glycosylation produced in Chinese hamster ovary cellsSemantic proximity Read ↗

Proteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO CellsSemantic proximity Read ↗

Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteinsSemantic proximity Read ↗

Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell cultureSemantic proximity Read ↗

Enhancing recombinant antibody yield in Chinese hamster ovary cellsSemantic proximity Read ↗

Multi‐omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer, and product qualitySemantic proximity Read ↗

Recent advances in (therapeutic protein) drug developmentSemantic proximity Read ↗

Microbial protein cell factories fight back?Semantic proximity Read ↗

High Throughput Morphological Screening Identifies Chemically Defined Media for Mesenchymal Stromal Cells that Enhances Proliferation and Supports Maintenance of Immunomodulatory FunctionSemantic proximity Read ↗

A concise guide to choosing suitable gene expression systems for recombinant protein productionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.