Article

Bioengineering vaccinia virus envelope protein to purify size-specific anticoagulant oligosaccharides from heterogeneous heparins

2023-06-10

Abstract excerpt

<title>Abstract</title> <p>Ultra-low molecular weight heparins (ULMWHs) are being used as anticoagulant drugs that exhibit a low risk, long lifetime and high efficacy. However, a robust and cost-effective purification methodology to isolate ULMWHs from naturally occurring heparins (HPs) is lacking. Vaccinia virus envelope protein A27 and a truncated variant (sA27-aa) bind specifically to HPs for virus/cell attach...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f28e2f4f-12ed-5523-bb0b-c4959089edb9
DOI: 10.21203/rs.3.rs-3031779/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bioengineering vaccinia virus envelope protein to purify size-specific anticoagulant oligosaccharides from heterogeneous heparinsDOI 10.21203/rs.3.rs-3031779/v1Read

Remarkable extension of PAI-1 half-life surprisingly brings no changes to its structure.Semantic proximity Read

A Procoagulant Peptide Analog of the SARS-CoV-2 Nucleocapsid C-terminal DomainSemantic proximity Read

Carrier-free low-molecular-weight heparin and lipid conjugate-based nano-anticoagulant with an albumin shuttling effectSemantic proximity Read

Optimization of factor VIII replacement therapy: can structural studies help in evading antibody inhibitors?Semantic proximity Read

High‐resolution structure of a polyomavirus VP1‐oligosaccharide complex: implications for assembly and receptor bindingSemantic proximity Read

Recombinant manufacturing of multispecies biolubricantsSemantic proximity Read

Annexin V--heparin oligosaccharide complex suggests heparan sulfate--mediated assembly on cell surfaces.Semantic proximity Read

Immobilized high-performance heparin lyase III for efficient preparation of low molecular weight heparin.Semantic proximity Read

SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight HeparinsSemantic proximity Read

Chemical biology tools for structure-function studies on heparan sulphates : decoding specificity in FGF signallingSemantic proximity Read

To generate functional anti-protease-activated receptor-4 (PAR4), a G protein-coupled receptor, antibodies through PAR4-mRNA-LNP immunizationSemantic proximity Read

Biochemical importance of glycosylation of plasminogen activator inhibitor-1.Semantic proximity Read