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Article

Bioengineering of coagulation factor VIII for improved secretion.

Blood - 1 May 2004

Miao Hongzhi Z, Sirachainan Nongnuch, Palmer Lisa, Kucab Phillip, Cunningham Michael A, Kaufman Randal J, Pipe Steven W

Abstract excerpt

Factor VIII (FVIII) functions as a cofactor within the intrinsic pathway of blood coagulation. Quantitative or qualitative deficiencies of FVIII result in the inherited bleeding disorder hemophilia A. Expression of FVIII (domain structure A1-A2-B-A3-C1-C2) in heterologous mammalian systems is 2 to 3 orders of magnitude less efficient compared with other proteins of similar size compromising recombinant FVIII...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14726380
DOI: 10.1182/blood-2003-10-3591

Genes

LMAN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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