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Single-Cell Targeted Transcriptomics Reveals Subset-Specific Immune Signatures Differentiating Asymptomatic and Cardiac Patients With Chronic Chagas Disease

21 May 2025

Abstract excerpt

BACKGROUND: Human infection with Trypanosoma cruzi leads to Chagas disease, which induces profound changes in the immune response across different cell subsets, influencing parasite control and disease pathology. Dissecting the functional characteristics of distinct immune cells in patients with the asymptomatic (indeterminate, IND) or the cardiac (CCC) clinical forms is crucial for unveiling mechanisms of...

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PMID: 40434116
DOI: 10.1093/infdis/jiaf269

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