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Recently activated CD4 T cells in tuberculosis express OX40 as a target for host-directed immunotherapy

19 Dec 2023

Abstract excerpt

Abstract After Mycobacterium tuberculosis (Mtb) infection, many effector T cells traffic to the lungs, but few become activated. Here we use an antigen receptor reporter mouse (Nur77-GFP) to identify recently activated CD4 T cells in the lungs. These Nur77-GFPHI cells contain expanded TCR clonotypes, have elevated expression of co-stimulatory genes such as Tnfrsf4/OX40, and are functionally more protective than...

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PMID: 38110410
DOI: 10.1038/s41467-023-44152-8

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