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Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1

3 Nov 2020

Abstract excerpt

Poly(ADP-ribose) Polymerase 2 (PARP2) is one of three DNA-dependent PARPs involved in the detection of DNA damage. Upon binding to DNA double-strand breaks, PARP2 uses nicotinamide adenine dinucleotide to synthesize poly(ADP-ribose) (PAR) onto itself and other proteins, including histones. PAR chains in turn promote the DNA damage response by recruiting downstream repair factors. These early steps of DNA damage...

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PMID: 33141820
DOI: 10.1371/journal.pone.0240932

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